The fundamental mechanism that underlies such seemingly disparate issues as autism, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and various other neurodegenerative conditions, is the process of inflammation. As you will note, this has been a central theme in my recent lectures, television programs, as well as books, as this is what current science is strongly supporting.
But it now looks as if this process, inflammation, may actually begin in the gut and subsequently affect the brain as a downstream mechanism.
I’ve been receiving a lot of questions lately about the effects of chemotherapy on the gut microbiome. What I’ve discovered is that there is, in fact, very little literature that explores this information. In reading that, we must recognize that about 90% of all the published literature dealing with the microbiome has been published only in the last 5 years.
Chemotherapy as a term actually encompasses a broad array of interventions. Various chemotherapeutic agents are used to target particular diseases. Related to cancer in general, about 650,000 Americans get chemotherapy, in one form or another, each year.
One recent study, looking at the effects of chemotherapy on the microbiome, evaluated patients who were receiving chemo to prepare them for stem cell therapy. These were patients with a form of blood cancer called non-Hodgkin’s lymphoma.
David Perlmutter, MD, FACN, ABIHM is a Board-Certified Neurologist and Fellow of the American College of Nutrition. He received his M.D. degree from the University of Miami School of Medicine where he was awarded the Leonard G. Rowntree Research Award for best research by a medical student. After completing residency training in Neurology, also at the University of Miami, Dr. Perlmutter entered private practice in Naples, Florida.
Dr. Perlmutter serves as an Associate Professor at the University of Miami School of Medicine. Dr. Perlmutter is a frequent lecturer at symposia sponsored by such medical institutions as Harvard University, the University of Arizona, Scripps Institute, New York University, and Columbia University. He has contributed extensively to the world medical literature with publications appearing in The Journal of Neurosurgery, The Southern Medical Journal, Journal of Applied Nutrition, and Archives of Neurology. He is the author of many books, including: The Better Brain Book, Raise a Smarter Child By Kindergarten, Power Up Your Brain: The Neuroscience of Enlightenment, the #1 New York Times Bestseller Grain Brain – The Surprising Truth About Wheat, Carbs, and Sugar – Your Brain’s Silent Killers, New York Times Bestseller The Grain Brain Cookbook, and New York Times Bestseller Brain Maker: The Power of Gut Microbes to Heal and Protect Your Brain – For Life, and is recognized internationally as a leader in the field of nutritional influences in neurological disorders.
Dr. Perlmutter has been interviewed on many nationally syndicated radio and television programs including 20/20, Larry King Live, CNN, Fox News, Fox and Friends, The Today Show, Oprah, Dr. Oz, Montel Across America, and The CBS Early Show. He serves as medical advisor to the Dr. Oz Show.